Cannabis can be used to help against headaches, and migraines are no exception. Studies suggest that weed can potentially make migraines less severe and less frequent. Because of this, many countries have migraines on the list of conditions eligible for a medical marijuana card. The ability to relieve migraine comes hand-in-hand with cannabis’ psychoactivity, which means that THC, or more specifically, high-THC strains are more effective against migraines. Strains with dominant Indica genetics are often preferred for headaches due to their ability to deeply relax both the mind and body. However, certain Sativa hybrids may also provide relief in some cases. For those experiencing migraines throughout the day, using Sativa strains during the daytime and Indica strains at night may be an effective approach. If you’re searching for the perfect strain, the list below provides a great starting point for finding effective strains to relieve migraines.
Best weed strains that may help migraines
Which cannabis strains could help relieve migraines?
Cannabis has shown potential in easing migraine symptoms, though its impact differs from person to person.
Strains high in CBD are often favored by those seeking migraine relief without the mind-altering effects, as CBD lacks psychoactive properties. These options are recognized for their soothing qualities and ability to reduce migraine-related discomfort.
Strains dominant in THC can help with pain, nausea, and inflammation for some users. However, while they may significantly alleviate migraine discomfort for certain individuals, others might find their symptoms intensified. The psychoactive nature of THC can also feel too strong for some, making it less ideal in those cases.
A 1:1 THC-to-CBD ratio strikes a balance, delivering relief without overwhelming effects. The method of use matters greatly. Inhaling through vaping or smoking provides fast-acting relief, useful when a migraine begins. Edibles, conversely, offer prolonged effects but may take 30 to 120 minutes to kick in.
Topical cannabis products, applied to the skin, may also help some with migraines, though they don’t produce the systemic effects of inhaled or ingested forms.
Which is better for migraines: Indica, Sativa, or hybrid strains? And what cannabinoids?
Certain cannabis strains can help alleviate the intense, pulsating pain of migraines while promoting a sense of tranquility, which is especially beneficial when stress or tension worsens symptoms.
In contrast, Sativa strains are celebrated for their energizing and mood-enhancing effects. They may be appropriate for those experiencing migraines alongside fatigue or for individuals who need to remain focused and active during the day. However, Sativas might not suit those prioritizing deep rest or relaxation to manage their condition.
Regarding cannabinoids, specific compounds excel in addressing migraine symptoms by targeting pain, inflammation, and discomfort. Tetrahydrocannabinol (THC), the primary psychoactive component in cannabis, provides pain-relieving and anti-inflammatory effects that may reduce migraine intensity, relax tight muscles, and ease nausea—a frequent migraine symptom. Cannabidiol (CBD), a non-psychoactive cannabinoid, is highly regarded for its healing properties. Free from THC’s mind-altering effects, CBD is often favored by those seeking migraine relief without cognitive fog.
Leading Cannabis Strains for Migraine Relief
To create a trustworthy list of cannabis strains that could ease migraines, we analyzed detailed user reviews and collaborated with our team of seasoned experts. Cannabis provides a diverse range of effects, influenced by differences in cannabinoid profiles, terpene makeup, and genetic backgrounds—from gentle, non-psychoactive CBD options to highly potent cultivars. Considering these factors, we’ve pinpointed top-performing strains that reliably offer quick and long-lasting relief for those experiencing migraines.
Trainwreck
A quintessential Sativa, Trainwreck ignites a vibrant, uplifting surge that fosters lasting happiness and mental clarity. As its initial intensity softens, a subtle physical calm settles in, offering full-body relaxation without heavy sedation or immobilization. Its balanced effects make it a dependable choice for mitigating migraines while maintaining a controlled, comfortable experience.
Purple Lemonade
This Indica-leaning hybrid, Purple Lemonade, exudes a lively aroma blending zesty citrus, juicy fruit, and distinct grape notes. Its flavor evokes a crisp lemonade infused with sweet, ripe berries. Rather than delivering a stimulating jolt, it promotes profound physical tranquility, fostering deep relaxation alongside a bright, uplifted mood. Users often report a serene, carefree mental state and comprehensive bodily relief, making it ideal for addressing muscle tension, cramps, migraines, and chronic stress, thanks to its high THC potency and calming properties.
Durban Poison
Durban Poison captivates with its sweet-tangy flavor profile, featuring notes of licorice, citrus, and pine. With THC levels ranging from 15% to 25%, it provides an energizing, mood-boosting effect perfect for daytime activities. This sociable strain enhances focus and motivation, making it a great fit for creative or outdoor pursuits. Medically, it’s prized for its ability to relieve stress, fatigue, and low mood, while its stimulating qualities may also help reduce headaches and migraines.
Passion Fruit
Passion Fruit is a rare, sativa-heavy hybrid with a strong THC content of about 22%. Its flavor leans tropical, with bright citrus and fruity highlights, while the aroma is sweet with earthy, spicy, and kush-like notes. The high hits fast, enhancing focus and creativity before shifting into a physically energizing yet pleasantly relaxing state. This balance of mental and physical effects makes it ideal for staying productive while managing stress. Medical users turn to Passion Fruit for relief from fatigue, pain, migraines, and long-lasting stress.
Grapefruit
Grapefruit, an energetic sativa-dominant hybrid, is celebrated for its bold citrus essence. It offers a sweet, zesty flavor with subtle sour notes, reminiscent of ripe grapefruit. The effects are uplifting and mental, boosting mood and fostering social ease, ideal for daytime use. Overuse may lead to lightheadedness or discomfort. Users often select Grapefruit to address symptoms of depression, chronic pain, epilepsy, or menstrual discomfort.
Garlic Budder
Garlic Budder, a potent indica-dominant hybrid, is valued for its high THC content, averaging around 30%. Its taste is rich and smooth, combining sharp garlic and cheesy tones with a hint of earthy sage. The aroma is equally intense, blending spicy herbs with nutty undertones. The experience begins with a burst of mental clarity and euphoria, gradually shifting into deep physical relaxation, often leading to sleep. Its strength makes Garlic Budder a popular choice for managing migraines, stress, or low mood.
Hash Plant
Hash Plant, a timeless strain from the 1980s Netherlands, features a moderate THC level of about 16%. Its scent is subtle yet distinctive, merging earthy, woody, and spicy notes with a smooth, hash-like flavor evocative of classic cannabis. The effects are calming, delivering a gentle, body-focused relaxation that may cause drowsiness or heavy rest. Medical users frequently choose Hash Plant to relieve insomnia, chronic pain, tension, or migraines.
Lemonberry
Lemonberry, a vibrant sativa-dominant hybrid, boasts an average THC level of approximately 22%. Its aroma and flavor are closely aligned, blending bright citrus, creamy vanilla, and sweet blueberry notes, with a lingering, dessert-like aftertaste. The effects are well-balanced, starting with an invigorating mental lift that sharpens creativity and focus. As the high develops, it encourages talkativeness and playful laughter before easing into a mild, soothing physical calm. Therapeutically, Lemonberry is often used to alleviate muscle tension, headaches, and persistent pain.
Strawberry Kush
Strawberry Kush offers a dynamic flavor experience, opening with a vivid burst of strawberry sweetness, followed by rich fruity and berry-like notes. As the taste evolves, it reveals deeper skunky, spicy, and earthy tones with a bold character. Its effects mirror this complexity, delivering a lively, euphoria-inducing high that uplifts the spirit while simultaneously soothing physical discomfort and tension. This strain keeps users alert and energized, avoiding drowsiness, making it a versatile option for migraine relief.
Gorilla Breath
Gorilla Breath brings an intensely uplifting sensation that gradually guides the body into prolonged relaxation. Its high THC content makes it a powerful ally for managing discomfort associated with conditions like glaucoma, headaches, eye pressure, low mood, and fatigue. Far from overwhelming, this strain delights with a rich flavor profile, combining chocolatey undertones with hints of fuel and smooth vanilla, offering a flavorful and effective option for migraine support.
Laughing Budha
Laughing Buddha is a predominantly sativa hybrid with a moderate THC level around 18%, making it a good choice for beginners. It offers a multi-layered flavor profile—citrus and pepper come through strongly, balanced by herbal spice and subtle woody undertones. Its aroma adds another dimension, bringing in earthy diesel notes and a touch of tropical fruit. The high is upbeat and mentally stimulating, often leading to a creative mindset and fits of laughter. As the experience continues, a relaxed calm sets in, frequently followed by drowsiness and a strong appetite. Thanks to its uplifting and lasting effects, this strain is commonly used by medical patients to manage conditions like glaucoma, migraines, and depression.
Black Domina
Black Domina leans almost entirely indica and typically contains around 21% THC. Its flavor is a rich mix of roasted coffee, nuts, and tangy citrus, while the scent is more layered—blending sweet berry tones with warm spices. The initial effects bring a wave of happiness and mental energy, often followed by deep relaxation. Before long, users may feel sleepy or even fully sedated. Its calming nature makes it a popular option for those dealing with chronic stress, nausea, migraines, and insomnia.
Strawberry Amnesia
Strawberry Amnesia is a flavorful sativa-dominant hybrid known for its high THC content, averaging 21%. True to its name, the taste is reminiscent of freshly picked strawberries, while the aroma adds an earthy depth. This strain is well-suited for daytime use due to its energizing and uplifting effects. Users often experience a burst of focus and creative energy, followed by a soothing sense of calm that can lead to sedation. While it’s a favorite among medical patients for issues like migraines, eye pressure, fatigue, and depression, some report anxiety at higher doses.