This is not signs of a calcium deficiency.......cal/mag is not the answer to everything.
Is it only one leaf??
Could be mechanical damage from hitting the edge of the potter, especially at night when the leaves are lowered and the fan blows on it.
Nutrient deficiencies will show across the entire plant, not just a single leaf or two.
Flushing the plant is pointless, it will achieve nothing.
Same with nematodes, what are they going to do??
If that leaf is really bothering you, just cut it off.
I really don't think you have anything to be worried about........unless it starts spreading across the plant.
Remember too..........no plant will ever have 100% perfect leaves, 100% of the time.